Mitsunori Matsuo

RESEARCH QUESTION: Does adenomyosis increase the risk of thromboembolic events, including both arterial and venous thromboembolism, compared with endometriosis, and what clinical factors may contribute to this association? DESIGN: This retr…

The reproductive tract microbiome plays a pivotal role in female fertility, with Lactobacillus-dominated communities maintaining a protective, low-pH environment. Dysbiosis-characterized by a reduction in Lactobacillus species and overgrowt…

Adenomyosis is an intractable gynecological disorder that can give rise to severe pelvic pain, heavy menstrual bleeding, and infertility, predominantly affecting women of reproductive age. The limited efficacy of current pharmacological int…

Adenomyomectomy, a therapeutic option for women with adenomyosis who wish to preserve their fertility, has been reported to pose a risk of developing placenta accreta spectrum (PAS) and uterine rupture in future pregnancies. However, the sp…

Adenomyosis often causes dysmenorrhea in women of reproductive age. Progestins such as levonorgestrel intrauterine system (LNG-IUS) are often used for treatment, but some patients experience progesterone resistance, showing poor treatment r…

Uterine adenomyosis is a common disease in women of reproductive age that causes dysmenorrhea, abnormal uterine bleeding, infertility, and obstetric complications. Rarely, adenomyosis can lead to abscess formation, which is refractory to an…

Levonorgestrel-releasing intrauterine system (LNG-IUS) relieves dysmenorrhea and heavy menstrual bleeding (HMB) in adenomyosis. However, its efficacy on health-related quality of life (HR-QOL) in patients with symptomatic adenomyosis remain…

Abstract Background Adenomyosis is a common gynecological disease in women of reproductive age and causes various symptoms such as dysmenorrhea and heavy menstrual bleeding. However, the influence of pregnancy on the progression of adenomyo…

Adenomyosis is a benign uterine disease that causes dysmenorrhea, heavy menstrual bleeding, and infertility; however, its pathophysiology remains unclear. Since signal transducer and activator of transcription 3 (STAT3) is crucial for endom…