David J. Handelsman

other 2026

Efficacy of Gonadotropin Therapy to Induce Spermatogenesis and Fertility in Men with Pathologic Gonadotropin Deficiency

The Journal of clinical endocrinology and metabolism ·doi:10.1210/clinem/dgaf588

CONTEXT: Gonadotropin treatment to induce spermatogenesis for gonadotropin-deficient men is the only medically treatable cause of male infertility. However, time-dependent analyses of fertility outcomes in large cohorts are lacking. We eval…

case-report 2025

Treatment With a Nonaromatizable Androgen for Transgender Man With a Hormone-sensitive Ovarian Cancer

JCEM case reports ·doi:10.1210/jcemcr/luaf081

Gender-affirming hormone therapy (GAHT) is increasingly prescribed to transgender men and gender diverse individuals to better align their affirmed gender identity and somatic phenotype, aiming to improve psychosocial well-being. However, t…

review 2014

Challenges to the measurement of oestradiol: comments on an endocrine society position statement

The Clinical biochemist. Reviews

observational 2014

Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions

The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2014-1913

CONTEXT: Aberrant sex steroid signaling is suggested to promote endometriosis growth by several mechanisms, and the tissue concentrations of sex steroids are key determinants of the hormone action. However, their concentrations are only sup…

observational 2012

Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels

The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2012-1154

CONTEXT: Aberrant estrogen synthesis and metabolism have been suggested to increase local estradiol (E2) concentration in endometriosis and thus to promote the growth of the lesions. However, tissue estrogen concentrations within the endome…