Hong Zhan

Endometriosis (EM) and chronic endometritis (CE) are both implicated in female infertility, yet the relationship between them remains incompletely understood. In this narrative review, we synthesize non-systematically selected clinical and …

The human endometrium is a highly regenerative tissue capable of undergoing scarless repair during the menstruation and postpartum phases. This process is mediated by endometrial adult stem/progenitor cells. During the healing of endometria…

BACKGROUND: Supervised Teaching Clinics (STCs) have emerged as an innovative approach to medical education, particularly in specialties like gynecology, where hands-on experience is crucial. Traditional clinical rotations often leave studen…

Endosalpingiosis is characterized by the presence of ectopic, benign glands with a fallopian tube-like ciliated epithelium. Florid cystic endosalpingiosis (FCE) is a rare type of endosalpingiosis and presents with tumor-like lesions. In gen…

Additional file 10. Differentially expressed genes of all M cells subclusters.

Additional file 11. Differentially expressed genes of FB clusters among endometriosis lesions, eutopic endometrium, and normal endometrium.

Additional file 12. Differentially expressed genes of CD4+ T cells along the pseudotime trajectory.

Additional file 1: Figure S1. Study flow chart. Single-cell RNA-sequencing. Figure S2 a-g. Enriched functions of FBs, Eps, ECs, T cells, NK cells, M cells, ast cells and neutrophils by GO and KEGG analyses. Figure S3. Single-cell RNA-seq an…

Additional file 3. Differentially expressed genes of FBs, M cells, NK cells, T cells, ECs, Eps, mast cells, and neutrophils.

Additional file 4. Differentially expressed genes of all FBs subclusters.

Additional file 5. Differentially expressed genes of FBs along the pseudotime trajectory.

Additional file 6. The relative ratio of immune cells in endometriosis lesions, eutopic endometrium, and normal endometrium.

Additional file 7. Differentially expressed genes of all T cells subclusters.

Additional file 8. The relative ratio of T cells subclusters in endometriosis lesions, eutopic endometrium, and normal endometrium.

Additional file 9. Differentially expressed genes of all NK cells subclusters.

BACKGROUND: Endometriosis is an oestrogen-dependent disease with an unclear aetiology and pathogenesis affecting 6-10% of the global female population, predominantly those of reproductive age. Herein, we profile the transcriptomes of approx…

Aims: Protein tyrosine phosphatase Src-homology-2-domain-containing phosphatase 2 (SHP2) and adaptor protein Grb2-associated binding protein 2 (GAB2) can bind to each other in various signal transduction. However, the expression of SHP2 and…

OBJECTIVE: To investigate the role(s) of hyaluronan synthase 2 (HAS2) and hyaluronan in disease progression of endometriosis and epidermal growth factor (EGF)-induced motility changes of endometriotic cells. DESIGN: A case-control experime…

CONTEXT; Deep dyspareunia (pelvic pain with sexual intercourse) affects half of women with endometriosis, but the underlying mechanisms are unclear. OBJECTIVE: To investigate whether nerve growth factor (NGF) and its receptor (TrkA/p75NTR) …

Endometriosis is present in 1 in 10 reproductive-age women, and half experience deep dyspareunia (pelvic pain with sexual intercourse). Our objective was to investigate nerve growth factor (NGF) and its receptors (TrkA/p75NTR) in endometrio…

STUDY QUESTION: Is phosphatase of regenerating liver-3 (PRL-3) associated with increased motility of endometriotic cells from endometrioma? SUMMARY ANSWER: Elevated PRL-3 promotes cytoskeleton reorganization, cell migration and invasion of…

Estradiol and its nuclear receptors, estrogen receptor (ER) α and ER-β, have important functions in endometriosis, and the transcriptional activity of these receptors is modulated by coactivators and corepressors. The steroid receptor RNA a…