Leonardo Jacobsen

No ORCID on file · 4 papers in corpus
review 2026
International journal of molecular sciences ·doi:10.3390/ijms27135678

Endometriosis is increasingly recognized as a chronic systemic disorder extending beyond the classical estrogen-dependent paradigm, integrating metabolic, immune, fibrotic, and nociceptive pathways that sustain lesion persistence and refrac…

review 2026
Expert opinion on pharmacotherapy ·doi:10.1080/14656566.2026.2749635

INTRODUCTION: Gestrinone is an androgenic progestin derived from 19-nortestosterone, in use for four decades in endometriosis and other estrogen-dependent conditions. It has largely disappeared from contemporary progestin taxonomies and is …

2025
·doi:10.20944/preprints202508.1818.v1

Background: The management of endometriosis-associated pain has traditionally focused on analgesic efficacy. However, with high-level evidence demonstrating therapeutic equivalence among principal hormonal classes, the paradigm has shifted …

review 2025
Biomedicines ·doi:10.3390/biomedicines13092294

Background: The management of endometriosis-associated pain has traditionally focused on analgesic efficacy. However, with high-level evidence demonstrating therapeutic equivalence among principal hormonal classes, the paradigm has shifted …