Liisu Saavalainen

BACKGROUND: Understanding of the impact of endometriosis on adverse early pregnancy outcomes has evolved in recent decades and has been partly attributed to endocrine dysfunction and chronic inflammation. However, data from population-based…

OBJECTIVE: To study first birth rates according to endometriosis subtype after surgical diagnosis among nulliparous women. DESIGN: Retrospective population-based cohort study using Finnish national registers, linking women with first surgi…

This study aimed to examine the frequency and type of menopausal hormone therapy (MHT) use after hysterectomy among women with surgically diagnosed endometriosis. A retrospective register-based cohort study identified women with a first sur…

OBJECTIVE: This study aimed to examine the frequency and type of menopausal hormone therapy (MHT) use after hysterectomy among women with surgically diagnosed endometriosis. METHOD: A retrospective register-based cohort study identified wo…

This study aimed to examine the frequency and type of menopausal hormone therapy (MHT) use after hysterectomy among women with surgically diagnosed endometriosis. A retrospective register-based cohort study identified women with a first sur…

BACKGROUND: Ovarian endometriosis is one of the most frequently diagnosed endometriosis subtypes. Surgical treatment may be required in selected cases, and indications for surgery have evolved over the years. However, recurrence is common a…

STUDY QUESTION: How does the burden of somatic disorders compare between women with surgically verified endometriosis diagnosed in adolescence or early adulthood, and matched women without a history of endometriosis? SUMMARY ANSWER: Women …

INTRODUCTION: Endometriosis is associated with educational and occupational challenges, including absenteeism and reduced capacity to study and work. We aimed to investigate long-term educational and occupational outcomes among women diagno…

INTRODUCTION: Endometriosis is associated with pain and infertility. However, little is known about birth rate among women with endometriosis on population level. We studied whether women with endometriosis have lower birth rate than women …

BACKGROUND: Endometriosis diagnosed in adults is associated with increased risk of various psychiatric disorders. However, little is known concerning psychiatric comorbidity and mortality due to external causes associated with endometriosis…

STUDY QUESTION: Do women with endometriosis have lower first live birth rate before surgical diagnosis than women without verified endometriosis? SUMMARY ANSWER: Compared to reference women, the incidence of first live birth was lower in w…

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genom…

Louis Marcellin, MD, PhD; Francois Goffinet, MD, PhD; Elie Azria, MD, PhD; Anne Thomin, MD; Charles Garabedian, MD, PhD; Jeanne Sibiude, MD, PhD; Eric Verspyck, MD, PhD; Martin Koskas, MD, PhD; Pietro Santulli, MD, PhD; Jessica Rousseau, Ph…

INTRODUCTION: Increasing awareness of endometriosis in adolescents requires data on the nature of the disease and its management. Our objective was to investigate the subtypes of surgically confirmed endometriosis in adolescents (aged <20 y…

Peer reviewed

Background Endometriosis is associated with increased risk of clear cell ovarian cancer and has even suggested being an etiological factor for this cancer. Association between endometriosis and extraovarian clear cell cancers is unclear. Th…

BACKGROUND: Endometriosis is associated with increased risk of clear cell ovarian cancer and has even suggested being an etiological factor for this cancer. Association between endometriosis and extraovarian clear cell cancers is unclear. T…

OBJECTIVE: To study reproductive outcomes, and pregnancy and delivery complications after conservative or operative treatment of rectovaginal endometriosis during long-term follow-up. DESIGN: Retrospective cohort study. SETTING: Universit…

INTRODUCTION: The association between endometriosis and breast cancer is unclear. We assessed the risk of breast cancer in women with surgically verified endometriosis, with special focus on the age at cancer diagnosis, time from endometrio…

STUDY QUESTION Is all-cause and cause-specific mortality increased among women with surgically verified endometriosis? SUMMARY ANSWER The all-cause and cause-specific mortality in midlife was lower throughout the follow-up among women with …

STUDY QUESTION: Is all-cause and cause-specific mortality increased among women with surgically verified endometriosis? SUMMARY ANSWER: The all-cause and cause-specific mortality in midlife was lower throughout the follow-up among women wi…

The aim of this thesis was to assess the risk of cancer according to the types of endometriosis and the risk of death among women with surgically verified endometriosis.\n\nIn first register-based cohort study, all women with an initial end…

We assessed the association of surgically verified endometriosis and risk of non-gynecological cancers according to the type of endometriosis (i.e., ovarian, peritoneal and deep infiltrating endometriosis). All diagnoses of endometriosis co…

We assessed the association of surgically verified endometriosis and risk of non-gynecological cancers according to the type of endometriosis (i.e., ovarian, peritoneal and deep infiltrating endometriosis). All diagnoses of endometriosis co…