Kenneth P. Winnard

lab-animal 2007

Endometriosis-induced vaginal hyperalgesia in the rat: effect of estropause, ovariectomy, and estradiol replacement

Pain ·doi:10.1016/j.pain.2007.09.022

Endometriosis (ENDO) is a painful disorder defined by extrauteral endometrial growths. It is created in rats by autotransplanting pieces of uterus (which form cysts), or, for shamENDO, fat (no cysts). ENDO induces vaginal hyperalgesia, like…

lab-animal 2006

Cross-organ interactions between reproductive, gastrointestinal, and urinary tracts: modulation by estrous stage and involvement of the hypogastric nerve

American journal of physiology. Regulatory, integrative and comparative physiology ·doi:10.1152/ajpregu.00455.2006

Central nervous system neurons process information converging from the uterus, colon, and bladder, partly via the hypogastric nerve. This processing is influenced by the estrous cycle, suggesting the existence of an estrous-modifiable centr…

lab-animal 2006

Opposing viscerovisceral effects of surgically induced endometriosis and a control abdominal surgery on the rat bladder

Fertility and sterility ·doi:10.1016/j.fertnstert.2006.03.026

OBJECTIVE: To determine, in rats, how surgically induced endometriosis and a control surgery (partial hysterectomy; sutures in abdomen) affects micturition thresholds and bladder vascular permeability. DESIGN: Two animal studies, each perf…