Saed GM

No ORCID on file · 4 papers in corpus
lab-animal 2026
Novel anti-Mullerian hormone receptor 2 binding peptide prevents chemotherapy-related ovarian follicle loss in a mouse model
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-026-03902-5

PURPOSE: Cancer treatments can deplete the ovarian follicle reserve causing infertility and early menopause, with subsequent decline in cardiovascular, cognitive, and overall health. Medical measures to prevent this chemotherapy-induced ova…

lab-animal 2025
Anti-Mullerian hormone (AMH) protects ovarian follicle loss by downregulating granulosa cell function in in vitro and in vivo models
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-025-03473-x

PURPOSE: AMH inhibits hormone production in luteinized granulosa cells (GCs) and stalls ovarian follicle development in vitro and in vivo. We sought to confirm AMH's mechanism of action through SMAD activation and investigate AMH inhibition…

lab-animal 2014
Nicotinamide adenine dinucleotide phosphate oxidase is differentially regulated in normal myometrium versus leiomyoma
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719114522552

Uterine fibroids are the most common benign tumor in women. The goal of this study was to investigate whether nicotinamide adenine dinucleotide phosphate oxidase (NOX), a major source of superoxide and subsequent oxidative stress, was diffe…

lab-animal 2013
Uterine fibroids are characterized by an impaired antioxidant cellular system: potential role of hypoxia in the pathophysiology of uterine fibroids
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-013-0029-7

PURPOSE: Fibroids are the most common smooth muscle overgrowth in women. This study determined the expression and the effect of hypoxia on two potent antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT) on human fibroid cells.…