Pamela Warner

ORCID: 0000-0002-2239-4827 · 5 papers in corpus
other 2025
Luteal phase oral dexamethasone administration alters endometrial steroid milieu
Endocrine connections ·doi:10.1530/ec-24-0638

We previously published the DexFEM trial, which showed that in women with heavy menstrual bleeding (HMB), oral dexamethasone reduces menstrual blood loss. Here, we report a pharmacodynamic analysis exploring the likely mechanism for this ef…

rct 2021
Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)
·doi:10.1016/j.ebiom.2021.103434

Background: The symptom of heavy menstrual bleeding (HMB) diminishes quality-of-life for many mid-age women and imposes substantial societal burden. We investigated our hypothesis that HMB reflects impaired endometrial vasoconstriction due …

rct 2012
Physiological sex steroid replacement in premature ovarian failure: randomized crossover trial of effect on uterine volume, endometrial thickness and blood flow, compared with a standard regimen
Human Reproduction ·doi:10.1093/humrep/des004

BACKGROUND: Premature ovarian failure (POF) is currently managed by non-physiological sex steroid regimens which are inadequate at optimizing uterine characteristics. Previous short-term studies have demonstrated some benefits of a sex ster…

rct 2009
Cardiovascular effects of physiological and standard sex steroid replacement regimens in premature ovarian failure
Hypertension (Dallas, Tex. : 1979) ·doi:10.1161/hypertensionaha.108.126516

Current hormone replacement therapy may not optimize cardiovascular health in women with premature ovarian failure. We compared the effects of physiological and standard sex steroid replacement regimens on cardiovascular health in these wom…

2009
Faculty Opinions recommendation of Comparison of efficacy of oral drotaverine plus mefenamic acid with paracervical block and with intravenous sedation for pain relief during hysteroscopy and endometrial biopsy.
·doi:10.3410/f.1162932.623560