Sumei Zhang

No ORCID on file · 4 papers in corpus
observational 2024
PD-L1 expression in ovarian clear cell carcinoma using the 22C3 pharmDx assay
Diagnostic pathology ·doi:10.1186/s13000-024-01510-4

BACKGROUND: Ovarian clear cell carcinoma (OCCC), well known for its chemoresistance to platinum-based chemotherapy, exhibited a good response in clinical trials of anti-PD-1/PD-L1 inhibitors. By assessing PD-L1 expression, we sought to dete…

lab-animal 2023
Exploring the cellular and molecular differences between ovarian clear cell carcinoma and high-grade serous carcinoma using single-cell RNA sequencing and GEO gene expression signatures
Cell & bioscience ·doi:10.1186/s13578-023-01087-3

The two most prevalent subtypes of epithelial ovarian carcinoma (EOC) are ovarian clear cell carcinoma (OCCC) and high-grade serous ovarian carcinoma (HGSC). Patients with OCCC have a poor prognosis than those with HGSC due to chemoresistan…

observational 2023
Tryptophan metabolism enzymes are potential targets in ovarian clear cell carcinoma
Cancer medicine ·doi:10.1002/cam4.6778

AIM: As the second most prevalent subtype of epithelial ovarian cancers, ovarian clear cell carcinoma (OCCC) is known for its chemoresistance to conventional platinum-based therapy. In this work, we examined the tryptophan (Trp) metabolism …

lab-animal 2022
The protective effect of 17 β-estradiol on human uterosacral ligament fibroblasts from postmenopausal women with pelvic organ prolapse
Frontiers in physiology ·doi:10.3389/fphys.2022.980843

This study aims to explore the protective effects of 17 β-estradiol on the human uterosacral ligament fibroblasts (hUSLFs) under static or stretched conditions. The experiments were performed on hUSLFs derived from pelvic organ prolapse (PO…