D. Hapangama

Abstract Study question Which clinical, treatment-related and informational factors are associated with satisfaction with hormonal therapies (HTs) in women with endometriosis and/or adenomyosis? Summary answer Satisfaction with HT was low, …

Abstract Endometriosis is a common and chronic condition causing pelvic pain and subfertility. Despite its prevalence, the pathophysiology of endometriosis remains poorly understood, due in part to disease complexity (superficial, ovarian a…

Abstract Study question What spatially resolved transcriptional differences distinguish matched eutopic endometrium, ectopic endometriosis and adenomyosis lesions with comparison to control endometrium? Summary answer Compartment and layer-…

Abstract Study question Do uterotonics have different effects on the inner (IM) and outer (OM) layers of the human pregnant and non-pregnant myometrium? Summary answer Oxytocin dose-dependently augments contractions in the IM and OM of the …

Endometriosis is associated with dyspareunia, dysmenorrhea and often severe pelvic pain as well as considered a chronic inflammatory disease, defined by the presence of endometrial tissue outside the uterine cavity. An important general con…

STUDY QUESTION: Is human endometrial leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) gene expression limited to the postulated epithelial stem cell niche, stratum basalis glands, and is it hormonally regulated? SUMMARY A…

BACKGROUND: Eukaryotic chromosomal ends are linear and are protected by nucleoprotein complexes known as telomeres. The complex structural anatomy and the diverse functions of telomeres as well as the unique reverse transcriptase enzyme, te…

STUDY QUESTION: How does regulation of telomerase activity (TA) in human endometrial epithelial cells (EEC) by ovarian hormones impact on telomere lengths (TL) and cell proliferation? SUMMARY ANSWER: Healthy endometrial epithelial cell pro…

BACKGROUND: Endometriosis is a metastatic disease without obvious tumorigenesis. Expression of S100P, S100A4, osteopontin (OPN) or anterior gradient homologue 2 (AGR2) proteins can induce metastasis but fail to induce tumorigenesis per se. …

BACKGROUND: We have recently shown that women with endometriosis express an increased amount of telomerase and nucleolin, with concomitant loss of γ-H2AX in eutopic endometrium. To further examine these selected factors that regulate cell f…

In women, a single dose of the antiprogestin mifepristone (RU486) in the secretory phase rapidly renders the endometrium unreceptive and is followed by endometrial breakdown and menstruation within 72 h. This model provides a system to iden…