Shi SQ

No ORCID on file · 3 papers in corpus
lab-animal 2013
Synthesis and antiprogestational properties of novel 17-fluorinated steroids
Steroids ·doi:10.1016/j.steroids.2013.04.003

Progesterone receptor (PR) plays a key role in reproductive functions, and compounds that inhibit progesterone action (antiprogestins) have potential use in the treatment of estrogen- and progesterone-dependent diseases, including uterine l…

lab-animal 2013
Synthesis and biological evaluation of partially fluorinated antiprogestins and mesoprogestins
Steroids ·doi:10.1016/j.steroids.2012.09.010

A series of antiprogestins have been synthesized by partially fluorinating the steroid molecule in positions relevant for receptor binding. By introducing fluorine at the exo-methylene of the 17 spirofuran ring, we obtained partial agonists…

lab-animal 2010
Pharmacologic actions of progestins to inhibit cervical ripening and prevent delivery depend on their properties, the route of administration, and the vehicle
American journal of obstetrics and gynecology ·doi:10.1016/j.ajog.2010.03.025

OBJECTIVE: The purpose of this study was to evaluate cervical changes and delivery at term during pregnancy in rats after various progestin treatments. STUDY DESIGN: Pregnant rats were treated by various routes and vehicles with progestero…