Akitoshi Tsuno

No ORCID on file · 12 papers in corpus
observational 2025
P-312 The effectiveness of laparoscopic aspiration and ethanol sclerotherapy (EST) for ovarian endometriomas
·doi:10.1093/humrep/deaf097.620

Abstract Study question Is EST for endometriomas effective and safe for infertility patients? Summary answer EST is an effective therapy for endometriomas. However, to avoid side effects and achieve efficient results, EST should be performe…

lab-animal 2014
Phosphatidylinositol-3 kinase-Akt-mammalian target of rapamycin signaling pathway mediates contractility of human endometriotic stromal cells: A promising new target for the treatment of endometriosis-associated fibrosis
·doi:10.1016/j.gmit.2014.07.001

Objective: To assess the involvement of phosphatidylinositol-3 kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) on the extracellular matrix contractility of endometriotic cells. Materials and methods: The effects of wortmannin, LY2940…

2014
Potential New Drugs for Endometriosis: Experimental Evidence
·doi:10.1007/978-4-431-54421-0_16
2012
Mechanism Underlying the Pathogenesis of Endometriosis Aberrant Expression of Apoptosis-Related Molecules in Endometriosis : A Possible
review 2011
Aberrant expression of apoptosis-related molecules in endometriosis: a possible mechanism underlying the pathogenesis of endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719110392059

Endometriosis, a disease affecting 3% to 10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue under the influence of estrogen. It is also becoming recognized as a condition in which ectopic endometr…

lab-animal 2011
Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target
Human Reproduction ·doi:10.1093/humrep/der203

BACKGROUND: Accumulating evidence suggests that various epigenetic aberrations play definite roles in the pathogenesis of endometriosis. We investigated the histone acetylation status in endometriosis and the application of the histone deac…

lab-animal 2011
Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2011-1503

CONTEXT: During the development of endometriotic lesions, excess fibrosis may lead to scarring and to the alterations of tissue function that are the characteristic features of this disease. Enhanced extracellular matrix contractility of en…

lab-animal 2010
Attachment to extracellular matrices is enhanced in human endometriotic stromal cells: a possible mechanism underlying the pathogenesis of endometriosis
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2010.10.026

OBJECTIVE: Endometriosis is characterized by the ectopic growth of endometrial tissue. One of the first steps to the spread of endometriosis in the peritoneal cavity is the attachment of endometriotic cells to peritoneal surfaces after they…

2010
Mevalonate-Ras Homology (Rho)/Rho-Associated Coiled-Coil-Forming Protein Kinase (ROCK)-Mediated Signaling Pathway as a Therapeutic Target for the Treatment of Endometriosis-Associated Fibrosis
·doi:10.2174/157436210791112154

Endometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue. Histologically, this disease is characterized by endometrial gland and stroma with surrounding dense fibrou…

lab-animal 2009
Decidualization attenuates the contractility of eutopic and ectopic endometrial stromal cells: implications for hormone therapy of endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2009-0207

CONTEXT: Decidualization of the endometrium involves the morphological and biochemical reprogramming of the estrogen-primed proliferative endometrial stromal compartment under the continuing influence of progesterone. OBJECTIVES: The aim o…

lab-animal 2009
Heparin is a promising agent for the treatment of endometriosis-associated fibrosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.02.057

OBJECTIVE: To assess the use of heparin for the medical treatment of endometriosis-associated fibrosis. DESIGN: The effects of heparin on the endometriotic stromal cells (ECSCs)-mediated contractility were investigated. SETTING: Research …

lab-animal 2009
Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.06.055

Simvastatin significantly inhibited the proliferation of endometriotic stromal cells, attenuated the collagen gel contraction mediated by these cells, and suppressed endometriotic stromal cell attachment to collagen fibers. Simvastatin is c…