Rakesh Chettier — Endo Lab

2020

Synthetic-lethal interactions between ATR inhibition and functional genetic and proteomic biomarkers to predict responses in endometriosis-associated cancers.

·doi:10.1200/jco.2020.38.15_suppl.e18000

e18000 Background: Endometriosis is a common gynecologic disorder proven to be a precursor to several cancer types. We developed a potent and selective inhibitor (ATRN-119) of a critical DNA damage response (DDR) protein kinase: the ataxia …

2019

Cytoskeletal and extra cellular matrix genes are key contributors in the pathogenesis of endometriosis

·doi:10.1016/j.fertnstert.2019.07.329

2019

Endometriosis risk allele in Wnt4 may interact with rare mutations in HDAC2 gene

·doi:10.1016/j.fertnstert.2019.07.952

2019

Somatic cancer driver mutations in endometriosis lesions contribute to secondary cancer risk

·doi:10.1016/j.fertnstert.2019.07.328

other 2019

Whole exome sequencing identifies hemizygous deletions in the UGT2B28 and USP17L2 genes in a three‑generation family with endometriosis

Molecular medicine reports ·doi:10.3892/mmr.2019.9818

Endometriosis is an enigmatic condition with an unknown etiology and a poorly understood pathogenesis. It is considered to appear from the interplay of many genetic and environmental factors, affecting up to 10% of women and represents a ma…

2018

Can genetic markers of endometriosis predict a patient’s responsiveness to leuprolide acetate?

·doi:10.1016/j.fertnstert.2018.07.057

case-report 2018

Co-existence of endometriosis with 13 non-gynecological co-morbidities: Mutation analysis by whole exome sequencing

Molecular medicine reports ·doi:10.3892/mmr.2018.9521

Endometriosis is an enigmatic condition with an unknown etiology and poorly understood pathogenesis and women with endometriosis represent a high-risk population group for a large category of chronic conditions. The study focused on a 67-ye…

2018

Whole exome sequencing identify hemizygous deletions in ugt2b28 and usp17l2 in a three-generation family with endometriosis

·doi:10.1016/j.fertnstert.2018.07.1085

2018

Whole exome sequencing of 137 endometriosis patients with a common ancestor in shakespeare’s england

·doi:10.1016/j.fertnstert.2018.07.1103

2017

DNA Testing to Predict Endometriosis: Implications for Referral for Minimally Invasive Surgery

·doi:10.1016/j.jmig.2017.08.075

2015

Exome sequencing of women with surgically confirmed endometriosis identifies new candidate genes

·doi:10.1016/j.fertnstert.2015.07.208

observational 2014

Endometriosis is associated with rare copy number variants

PloS one ·doi:10.1371/journal.pone.0103968

Endometriosis is a complex gynecological condition that affects 6-10% of women in their reproductive years and is defined by the presence of endometrial glands and stroma outside the uterus. Twin, family, and genome-wide association (GWA) s…

2014

Mutations in the GnRH signaling pathway are risk factors for endometriosis

·doi:10.1016/j.fertnstert.2014.07.037

2014

Next generation sequencing of families with endometriosis identifies new genomic regions likely to contribute to heritability

·doi:10.1016/j.fertnstert.2014.07.260

2014

Rare mutations in WNT signaling pathways are risk factors for endometriosis

·doi:10.1016/j.fertnstert.2014.07.038

observational 2013

Genome-wide association study link novel loci to endometriosis

PloS one ·doi:10.1371/journal.pone.0058257

Endometriosis is a common gynecological condition with complex etiology defined by the presence of endometrial glands and stroma outside the womb. Endometriosis is a common cause of both cyclic and chronic pelvic pain, reduced fertility, an…

2012

Comparing apples and oranges: molecular pathogenesis of endometriosis varies by patient ancestry

·doi:10.1016/j.fertnstert.2012.07.488

2012

Genetic prediction of endometriosis in women seeking assisted reproductive technologies

·doi:10.1016/j.fertnstert.2012.07.923

2012

KRAS and LCS6 show no evidence of association with endometriosis

·doi:10.1016/j.fertnstert.2012.07.785

2012

Rare genetic variants useful for non-invasive diagnosis and prediction of endometriosis

·doi:10.1016/j.fertnstert.2012.07.038

2012

Replication of endometriosis GWAS signal across multiple studies support involvement of WNT4

·doi:10.1016/j.fertnstert.2012.07.1153

2012

Sipping from the firehose: complete genome sequencing of endometriosis patients

·doi:10.1016/j.fertnstert.2012.07.243