William D. Schlaff
No ORCID on file
· 23 papers in corpus
other
2023
OBJECTIVE: Evaluate the efficacy and safety of elagolix, a GnRH antagonist, to treat polycystic ovarian syndrome (PCOS). DESIGN: A phase 2, multicenter, double-blind, randomized, placebo-controlled trial. SETTING: Outpatient and academic …
review
2021
Bone mineral density (BMD) changes during the life span, increasing rapidly during adolescence, plateauing in the third decade of life, and subsequently entering a phase of age-related decline. In women, menopause leads to accelerated bone …
meta-analysis
2018
OBJECTIVE: To review the available clinical evidence on the use of combined hormonal contraceptive (CHC) agents (estrogen [E]-progestin combinations) for the treatment of endometriosis-related pain. DESIGN: A systematic review of the MEDLI…
rct
2016
STUDY QUESTION: Does fertility-related quality of life (FertiQOL) differ by infertility diagnosis between women with polycystic ovary syndrome (PCOS) and their partners, compared with couples with unexplained infertility (UI)? SUMMARY ANSW…
review
2014
Pain is among the foremost complaints of women seeking gynecological consultation, yet the diagnosis is often limited to endometriosis. Chronic Pelvic Pain discusses how to diagnose a broad scope of underlying conditions presenting in relat…
review
2014
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2014
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rct
2013
Objectives: To determine if low-dose estrogen replacement can be added to GnRH agonist therapy after three months to reduce hypoestrogenic symptoms while allowing continued relief of pain in patients with endometriosis. Materials and Method…
2012
Dr. Worly is Assistant Professor, and Dr. Schlaff is Professor and Chair, Department of Obstetrics and Gynecology, Jefferson Medical College, Thomas Jefferson University, 834 Chestnut St, Ste 400, Philadelphia, PA 19107; E-mail: [email prot…
review
2012
Dr. Worly is Assistant Professor, and Dr. Schlaff is Professor and Chair, Department of Obstetrics and Gynecology, Jefferson Medical College, Thomas Jefferson University, 834 Chestnut St, Ste 400, Philadelphia, PA 19107; E-mail: [email prot…
observational
2012
BACKGROUND: Although histological dating of endometrial biopsies provides little help for prediction or diagnosis of infertility, analysis of individual endometrial proteins, proteomic profiling and transcriptome analysis have suggested sev…
review
2007
Part I Reproductive Endocrinology and the Regulation of Menses Steroids and prostaglandins in reproductive medicine The normal Menstrual cycle Normal and abnormal pubertal development Primary amenorrhea Hyperandrogenic disorders and PCOS Se…
rct
2006
OBJECTIVE: To compare the efficacy and safety of SC depot medroxyprogesterone acetate (DMPA-SC 104) with that of leuprolide acetate in treatment of endometriosis. DESIGN: Phase 3, multicenter, randomized, evaluator-blinded, comparator-cont…
observational
2006
Utility of screening for other causes of infertility in women with "known" polycystic ovary syndrome
We investigated the prevalence of abnormal screening results (questionnaire and testing for other causes of oligo-ovulation, male or tubal factor infertility) in a group of 1,313 oligo-ovulatory women (included and excluded subjects) whose …
case-report
2005
BACKGROUND: Advances in radiation therapy have led to long term survival in young patients with Hodgkin's disease. Oophoropexy may reduce ovarian damage and preserve hormonal production and future fertility. When ovarian ligaments are short…
case-report
2003
Amenorrhea is a common symptom that generally presents to the gynecologist for evaluation and therapy during adolescence. Its presence, in combination with an anomaly of the vagina and a pelvic mass, suggests many possible etiologies whose …
observational
2001
OBJECTIVE: To determine if extended treatment with doxycycline before and after an in vitro fertilization (IVF) procedure can minimize the detrimental effect of a hydrosalpinx. DESIGN: Retrospective analysis. SETTING: University IVF progr…
review
2000
The treatment of women with endometriosis can be a challenge. Therapeutic strategies must be tailored to the individual symptoms, age, and desire for fertility. Medical therapy continues to be based on endocrine treatment, such as oral cont…
other
1996
PURPOSE: Our purpose was to determine the effect of Synthetic Serum Substitute (SSS) versus serum supplementation on fertilization rates and subsequent development of embryos from patients undergoing IVF. PROCEDURE: Experiment I compared t…
other
1992
OBJECTIVE: To study the potential application of the cavitron ultrasonic surgical aspirator (CUSA) in gynecological laparoscopic surgery using a rabbit animal model. DESIGN: Twenty-six rabbits were prospectively randomized into two groups.…
other
1992
Patients undergoing human menopausal gonadotropin (hMG) superovulation were reviewed retrospectively to determine whether fecundity was greater for intrauterine insemination (IUI) than timed intercourse. Forty patients with unexplained infe…
lab-animal
1991
The purpose of our study was to characterize the time-dependent effect of gonadotropin-releasing hormone analog (GnRH-a) therapy on endometriosis explant using the rat model. Endometriosis was induced in 60 mature female rats. One group of …
other
1990
Between 1977-1989, 29 women with symptomatic endometriosis were treated with megestrol acetate by the Johns Hopkins Division of Reproductive Endocrinology. All had previously received one or more alternative medical treatments for endometri…