I.S. Fraser — Endo Lab

review 2014

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research

Fertility and sterility ·doi:10.1016/j.fertnstert.2014.07.1209

OBJECTIVE: To harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, and storage of human tissues relevant to endometriosis. DESIGN: An international collaboration involv…

review 2014

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: II. Clinical and covariate phenotype data collection in endometriosis research

Fertility and sterility ·doi:10.1016/j.fertnstert.2014.07.1244

OBJECTIVE: To harmonize the collection of nonsurgical clinical and epidemiologic data relevant to endometriosis research, allowing large-scale collaboration. DESIGN: An international collaboration involving 34 clinical/academic centers and…

review 2014

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research

Fertility and sterility ·doi:10.1016/j.fertnstert.2014.07.1208

OBJECTIVE: To harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, and storage of fluid biospecimens relevant to endometriosis. DESIGN: An international collaboration i…

review 2011

Regulatory T cells and other leukocytes in the pathogenesis of endometriosis

Journal of Reproductive Immunology ·doi:10.1016/j.jri.2010.11.004

Endometriosis is a common and puzzling gynaecological condition which shows a great deal of variability between women. It affects up to 15% of all women of reproductive age. There is a strong familial component, but the aetiology and pathog…

2009

A multicenter, double-blind, randomized, placebo-controlled study of oral estradiol valerate/dienogest for the treatment of heavy and/or prolonged menstrual bleeding

·doi:10.1016/j.fertnstert.2009.07.123

observational 2009

Neuroendocrine cells in eutopic endometrium of women with endometriosis

Human Reproduction ·doi:10.1093/humrep/dep379

BACKGROUND: Endometriosis is a common gynaecological disease, but the pathogenesis of endometriosis and pathophysiological basis for endometriosis-associated painful symptoms are still uncertain. Little is known about neuroendocrine (NE) ce…

observational 2008

Macrophages and nerve fibres in peritoneal endometriosis

Human Reproduction ·doi:10.1093/humrep/den483

BACKGROUND: Endometriosis is considered to be an inflammatory disease, and macrophages are the most numerous immune cells in endometriotic lesions. However, the mechanisms underlying the elevation of macrophages and their role in the pathog…

review 2000

Endometrial-myometrial interface: relationship to adenomyosis and changes in pregnancy

Obstetrical & gynecological survey ·doi:10.1097/00006254-200006000-00025

The endometrial-myometrial interface (EMI) is an important region of the human uterus, which has attracted little research attention. This mucosal-muscular interface has characteristic features when compared with other similar interfaces in…

review 1999

Regulating menstrual bleeding. A prime function of progesterone

The Journal of reproductive medicine

Progesterone plays a crucial role in the coordination of endometrial breakdown as well as in the determination and regulation of menstrual blood loss and endometrial transudation of fluid. Furthermore, long-term exposure of the endometrium …

rct 1981

Efficacy of mefenamic acid in patients with a complaint of menorrhagia

Obstetrics & Gynecology

Sixty-nine patients with a convincing history of menorrhagia completed a 4-cycle double-blind randomized placebo-controlled crossover trial of mefenamic acid taken during menstruation. Only 30 of these patients demonstrated objective menorr…