{"paper_id":"f2a35229-24b6-44cf-ae22-91a2e1fb9788","body_text":"Endometriosis as a Systemic Disease: A Multidisciplinary Clinical Protocol\nAuthors/Creators\n- 1. Viktoriya Hudziak Fertility Management Center\nDescription\nEndometriosis is a chronic, oestrogen-dependent inflammatory disease affecting an estimated 10% of women of reproductive age. The mean diagnostic delay is 6–7 years.\nCurrent evidence supports viewing endometriosis beyond a purely gynaecological condition: it combines peripheral inflammation, central sensitisation, genetic susceptibility and associations with other chronic conditions.\nObjective. To provide a structured protocol integrating the contributions of the gynaecological (endometriosis) surgeon, reproductive medicine specialist, radiologist, pain specialist, colorectal surgeon, urologist, psychologist, pelvic-floor physiotherapist, dietitian and other team members.\nMethods. The protocol synthesises the ESHRE 2022 guideline, NICE NG73, ACOG guidance, the IDEA ultrasound and WES classification consensus statements, Cochrane reviews and key randomised trials (Section 4). Primary sources and GRADE-based guidelines were prioritised.\nResults. A six-step patient pathway is proposed:\n(1) clinical suspicion and early recognition;\n(2) non-invasive imaging;\n(3) empirical therapy and a personalised plan;\n(4) surgery in a centre of expertise where indicated;\n(5) recovery, rehabilitation and long-term suppression;\n(6) outcome monitoring (PROMs) and comorbidity screening.\nConclusions. Managing endometriosis as a chronic, multisystem condition through a coordinated team may improve pain control, quality of life and reproductive outcomes. The protocol requires local adaptation and independent expert verification before clinical use\nFiles\nEndometriosis_Systemic_Disease_MDT_Clinical_Protocol_v1.0.0_Viktoriya_Hudziak.pdf\nAdditional details\nAdditional titles\n- Alternative title (English)\n- Evidence-based diagnosis, medical and surgical treatment, fertility care, rehabilitation and long-term follow-up\nRelated works\n- Is supplemented by\n- Report: 10.5281/zenodo.22129194 (DOI)\n- Report: 10.5281/zenodo.20364043 (DOI)\n- Report: 10.5281/zenodo.20380264 (DOI)","source_license":"CC0","license_restricted":false}