{"paper_id":"21d5a201-e503-4583-8f6d-c67f70b7c99d","body_text":"MORPHOLOGICAL CHANGES AND TISSUE REPAIR IN THE INTESTINE AND MESENTERY FOLLOWING EXPERIMENTAL BLUNT ABDOMINAL TRAUMA\nSobitkhanov ., Nishanov ., Sadykov .\n← Back to PRACTICAL SURGERYPOLYMORPHISMS OF THE WNT4 (RS7521902, RS16826658), GREB1 (RS13394619), FN1 (RS1250248), IL1A (RS6542095), AND VEZT (RS10859871) GENES AND ESTROGEN METABOLISM PARAMETERS (16α-OH-E1 AND 2-OH-E1) IN THE PATHOGENESIS OF ENDOMETRIOSIS (LITERATURE REVIEW)\nAbstract\nKeywords\nMetrics & attention\nRelated articles\nMORPHOLOGICAL CHANGES AND TISSUE REPAIR IN THE INTESTINE AND MESENTERY FOLLOWING EXPERIMENTAL BLUNT ABDOMINAL TRAUMA\nCLINICAL EFFICACY OF MINIMALLY INVASIVE TECHNOLOGIES IN THE TREATMENT OF OBSTRUCTIVE JAUNDICE ASSOCIATED WITH CHOLEDOCHOLITHIASIS\nMODERN ASPECTS OF RADIOLOGICAL DIAGNOSIS OF ACUTE SURGICAL DISEASES OF THE ABDOMEN\nINTESTINAL FUNCTIONAL RECOVERY AND LATE COMPLICATIONS FOLLOWING EXPERIMENTAL BLUNT ABDOMINAL TRAUMA: THE ROLE OF INJURY SEVERITY AND TREATMENT STRATEGY\nOriginal research\nPRACTICAL SURGERY, Vol. 3, No. 3 (2026)\n- Nadjmitdinova D.A.✉\nReceived: September 20, 2026Accepted: September 30, 2026Published: October 2, 2026\nEndometriosis is a chronic estrogen-dependent inflammatory disease with a significant hereditary component; twin studies estimate its heritability at approximately 50% [1, 8]. Genome-wide association studies have identified dozens of risk loci, most of which are located in or near genes involved in hormonal regulation, cell adhesion, inflammation, and tissue remodeling [1, 2, 11]. The polymorphisms investigated in this review represent several interconnected pathways involved in the pathogenesis of endometriosis.\nGeneral considerations. To systematize the available literature, predominantly published during 2021–2026, on the role of polymorphisms in the WNT4 (rs7521902, rs16826658), GREB1 (rs13394619), FN1 (rs1250248), IL1A (rs6542095), and VEZT (rs10859871) genes, as well as estrogen metabolism parameters (16α-OH-E1 and 2-OH-E1), in the pathogenesis of endometriosis. A separate objective of this review is to assess the reproducibility of these markers across different populations and to determine whether evidence exists regarding their combined analysis.\nConclusions. The studied polymorphisms represent different but interconnected pathogenic pathways, and their potential diagnostic and prognostic significance may therefore be more appropriately evaluated as part of a comprehensive panel rather than individually.\n- endometriosis, estrogen metabolites, gene polymorphisms.\n3 views · 8 downloads · pp. 39–48\nSobitkhanov ., Nishanov ., Sadykov .\nSeptember 19, 2026pp. 13–24DOI12 views22 downloads\nZiyayev S., Boboyev ., Tojiboev A.\nSeptember 19, 2026pp. 32–38DOI7 views21 downloads\nNadjmitdinov ., Khujakov M.\nSeptember 19, 2026pp. 25–31DOI6 views23 downloads\nSadikov ., Nishanov M., Sobitkhanov M.\nSeptember 18, 2026pp. 4–12DOI11 views17 downloads","source_license":"CC0","license_restricted":false}